Repeated intravascular ultrasound imaging in cardiac transplant recipients does not accelerate transplant coronary artery disease.

Content Provider	Semantic Scholar
Author	Ramasubbu, Kumudha Schoenhagen, Paul Balghith, Mohammed Ali Brechtken, Johannes Ziada, Khaled M. Kapadia, Samir R. Hobbs, Robert E. Rincón, Gustavo Andrés Nissen, Steven E. Tuzcu, Emin Murat
Copyright Year	2003
Abstract	OBJECTIVES This study was designed to examine the impact of repeated intravascular ultrasound (IVUS) examinations on transplant coronary artery disease (CAD). BACKGROUND Serial IVUS is the most accurate method for early detection and surveillance of transplant CAD. However, the long-term safety of serial IVUS exams is not well described. Accordingly, we examined the impact of repeated IVUS examinations on transplant CAD. METHODS We examined 226 transplant recipients who underwent one or more IVUS examinations and coronary angiography at least one year after the last IVUS exam. The coronary angiograms were analyzed using quantitative coronary angiography. Vessel diameters, frequency, and severity of stenoses in IVUS-imaged and nonimaged coronary arteries were compared. In a subgroup analysis of 31 patients, angiographic lumen diameters were measured at baseline (within eight weeks of transplantation) and during follow-up (after two, three, or four IVUS studies). RESULTS In the 226 patients, 548 coronary arteries were previously imaged by IVUS and 130 arteries were not imaged by IVUS. On subsequent angiograms, stenoses were observed in 16.2% (21/130) of nonimaged arteries and 19.5% (107/548) of imaged arteries (p = 0.38). The arterial diameters of nonimaged and imaged arteries were not significantly different (p = 0.07), regardless of the number of IVUS exams and duration of follow-up. Subgroup analysis revealed a significant decrease in vessel lumen diameter over time in nonimaged as well as imaged arteries. The magnitude of the diameter decrease was not significantly different between the two groups. CONCLUSIONS Repeated IVUS examinations following heart transplantation do not result in angiographically evident acceleration of transplant CAD. Therefore, serial IVUS imaging is a safe method for the detection and surveillance of transplant CAD.
File Format	PDF HTM / HTML
DOI	10.1016/S0735-1097(03)00339-5
PubMed reference number	12767657
Journal	Medline
Volume Number	41
Issue Number	10
Alternate Webpage(s)	http://www.onlinejacc.org/content/accj/41/10/1739.full.pdf
Alternate Webpage(s)	https://doi.org/10.1016/S0735-1097%2803%2900339-5
Journal	Journal of the American College of Cardiology
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article