Cerebral Autosomal-Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy – CADASIL

Content Provider	Semantic Scholar
Author	Brondani, Rosane Almeida, Andrea Garcia De Mota, Suelen Mandelli Krammer, Bárbara Reis Marafon, Martina Camerini Mazzocato, Eduardo De Carvalho Bianchini, Larissa Araújo, Vicenzo Zarpellon De Bianchin, Marino Muxfeldt
Copyright Year	2016
Abstract	We report here neuroimaging findings of a  41 years-old female with molecular diagnosis of CADASIL (Cerebral Autosomal-Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy). CADASIL, the most common form of hereditary stroke, is characterized by headaches and relapsing strokes. More than 95% of patients present mutations of NOTCH3 gene. MRI, the best neuroimaging modality to investigate CADASIL can show lacunar infarcts and less-well demarcated T2 weighted hyperintensities characteristically located in subcortical white matter. There is no specific treatment for CADASIL. Anti-platelet agents such as aspirin might help to prevent new strokes. Other symptoms, like headache, seizures, or other neuropsychiatric manifestations should be appropriately treated.
Starting Page	252
Ending Page	253
Page Count	2
File Format	PDF HTM / HTML
DOI	10.4322/2357-9730.66306
Volume Number	36
Alternate Webpage(s)	https://www.lume.ufrgs.br/bitstream/handle/10183/158780/001012855.pdf?isAllowed=y&sequence=1
Alternate Webpage(s)	https://seer.ufrgs.br/index.php/hcpa/article/download/66306/pdf
Alternate Webpage(s)	https://doi.org/10.4322/2357-9730.66306
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article