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Gold nanorods as molecular contrast agents in photoacoustic imaging: the promises and the caveats.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Srirang Manohar Ungureanu, Constantin Leeuwen, Ton G. Van |
| Copyright Year | 2011 |
| Abstract | Rod-shaped gold nanoparticles exhibit intense and narrow absorption peaks for light in the far-red and near-infrared wavelength regions, owing to the excitation of longitudinal plasmons. Light absorption is followed predominantly by non radiative de-excitation, and the released heat and subsequent temperature rise cause strong photoacoustic (optoacoustic) signals to be produced. This feature combined with the relative inertness of gold, and its favorable surface chemistry, which permits affinity biomolecule coupling, has seen gold nanorods (AuNR) attracting much attention as contrast agents and molecular probes for photoacoustic imaging. In this article we provide an short overview of the current status of the use of AuNR in molecular imaging using photoacoustics. We further examine the state of the art in various chemical, physical and biochemical phenomena that have implications for the future photoacoustic applications of these particles. We cover the route through fine-tuning of AuNR synthetic procedures, toxicity reduction by appropriate coatings, in vitro cellular interactions of AuNRs, attachment of targeting antibodies, in vivo fate of the particles and the effects of certain light interactions with the AuNR. |
| Starting Page | 389 |
| Ending Page | 400 |
| Page Count | 12 |
| File Format | PDF HTM / HTML |
| DOI | 10.1002/cmmi.454 |
| PubMed reference number | 22025339 |
| Journal | Medline |
| Volume Number | 6 |
| Issue Number | 5 |
| Alternate Webpage(s) | https://www.utwente.nl/en/tnw/bmpi/publications/pdfs/CMMI_SManohar_etal.pdf |
| Alternate Webpage(s) | http://doc.utwente.nl/80015/1/gold_nanorods.pdf |
| Alternate Webpage(s) | https://doi.org/10.1002/cmmi.454 |
| Journal | Contrast media & molecular imaging |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
