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Isolation and Identification of Circulating Tumor Cells (CTCs) from breast and prostate cancer patients
| Content Provider | Semantic Scholar |
|---|---|
| Author | Adams, Daniel E. Alpaugh, R. Katherine Cristofanilli, Massimo Martin, Stuart S. Chumsri, Saranya Charpentier, Monica S. Bergan, Raymond Ogden, Irene M. Zhu, Peixuan Makarova, Olga V. Li, Shuhong Amstutz, Platte T. Tang, Cha-Mei |
| Copyright Year | 2014 |
| Abstract | Microfiltration is an increasingly popular method for isolating circulating tumor cells (CTCs) from the peripheral blood of cancer patients with solid tumors 2-4 . The microfiltration approach can be used on peripheral blood as a noninvasive “liquid biopsy” for precision cancer detection, regardless of surface marker expression 2-4 . Here we describe the use of CellSieve TM microfilters to isolate and subtype CTCs from the peripheral blood of breast, and prostate cancer patients. As it is accepted that CTCs isolated from patient samples represent a highly heterogeneous population with varying degrees of epithelial/mesenchymal differentiation, microfilter isolation may be optimal for the purification of all CTC subtypes. We hypothesize that CTCs from these two different epithelial malignancies can be identified and grouped into distinct subtypes by morphological characterization. |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://www.creatvmicrotech.com/Documents/Posters/NCI-NIBIB_POC_2014.pdf |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
