NDLI: Effect of Fruit Extract of Prunus mume on the Scavenging Activity of Reactive Oxygen Species and Melanin Production in B16F1 Cells

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Effect of Fruit Extract of Prunus mume on the Scavenging Activity of Reactive Oxygen Species and Melanin Production in B16F1 Cells

Content Provider	Semantic Scholar
Author	Park, Hyeong-Joon Kim, Moojoon Oh, Yunghee
Copyright Year	2012
Abstract	Prunus mume has been traditionally used as a medicinal food in Korea, Japan, and China. In particular, this fruit has been reported to have beneficial biological effects on gastritis and gastric ulcers. However, its action in relation to skin whitening has remained unclear. Accordingly, the effects of fruit extract of P. mume related to antioxidation and skin whitening were examined in this study. First, using the MTT assay, it was observed that fruit extract of P. mume below 0.1% has no cytotoxicity in B16-F1 cells as a result of cell viability. Second, the direct scavenging effects and the reducing power of the fruit extract of P. mume were evaluated in vitro on DPPH radicals, hydrogen peroxide, and superoxide. It exhibited high reducing power and scavenging activity on the aforementioned reactive oxygen species. Furthermore, we found that its protective effect against genomic DNA damage related to oxidative stress was increased in a dose-dependent manner. In addition, the fruit extract of P. mume had an inhibitory effect on melanin production induced by L-dopa. In addition, it reduced the expression level of NRF-2, SOD-1, and SOD-2 related to antioxidation in western blot analysis. These results suggest that fruit extract of P. mume could exert a whitening effect through inhibition of melanin production by its antioxidant effect.
Starting Page	936
Ending Page	942
Page Count	7
File Format	PDF HTM / HTML
DOI	10.5352/JLS.2012.22.7.936
Volume Number	22
Alternate Webpage(s)	http://ocean.kisti.re.kr/downfile/volume/ksls/SMGHBM/2012/v22n7/SMGHBM_2012_v22n7_936.pdf
Alternate Webpage(s)	https://doi.org/10.5352/JLS.2012.22.7.936
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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