Zinc(II) complexes of carboxamide derivatives: Crystal structures and interaction with calf thymus DNA

Content Provider	Semantic Scholar
Author	Mondal, Biplab Sen, Buddhadeb Zangrando, Ennio Chattopadhyay, Pabitra
Copyright Year	2015
Abstract	AbstractTwo mononuclear zinc(II) complexes of newly designed carboxamide derivatives, formulated as [Zn(L1)3](ClO4)2 (1) and [Zn(L2)3](ClO4)2 (2) [where L1 = N-(furan-2-ylmethyl)-2-pyridinecarboxamide and L2 = N-(thiophen-2-ylmethyl)-2-pyridine-carboxamide], have been isolated in pure form in the reaction of perchlorate salts of Zn(II) with ligands L1 and L2, respectively. The two complexes were characterized by physicochemical and spectroscopic tools, and by X-ray crystal structures of both ligands and the complex 1. In complex 1, zinc(II) is chelated by three ligands with a distorted octahedral geometry. The DNA-binding properties of zinc complexes 1 and 2 have been investigated by spectroscopic methods and viscosity measurements. The results suggest that both complexes 1 and 2 bind to DNA in an intercalation mode between the uncoordinated furan or thiophene chromophore and the base pairs of DNA. Graphical AbstractTwo distorted octahedral mononuclear zinc(II) complexes of newly designed carboxamide ligands bind to calf thymus DNA in an intercalation mode.
Starting Page	1747
Ending Page	1755
Page Count	9
File Format	PDF HTM / HTML
DOI	10.1007/s12039-015-0954-3
Volume Number	127
Alternate Webpage(s)	https://arts.units.it/retrieve/handle/11368/2869106/117842/12039_2015_954_MOESM1_ESM.pdf
Alternate Webpage(s)	https://arts.units.it/retrieve/handle/11368/2869106/117841/Zinc(II)%20complexes%20of%20carboxamide%20derivatives.%20Crystal%20structures%20and%20interaction%20with%20calf%20thymus%20DNA.pdf
Alternate Webpage(s)	https://doi.org/10.1007/s12039-015-0954-3
Journal	Journal of Chemical Sciences
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article