NDLI: Enhancing recovery after stroke with noradrenergic pharmacotherapy: a new frontier?

Please wait, while we are loading the content...

Enhancing recovery after stroke with noradrenergic pharmacotherapy: a new frontier?

Content Provider	Semantic Scholar
Copyright Year	2000
Abstract	Despite much progress in stroke prevention and acute intervention, recovery and rehabilitation have traditionally received relatively little scientific attention. There is now increasing interest in the development of stroke recovery drugs and innovative rehabilitation techniques to promote functional recovery after completed stroke. Experimental work over the past two decades indicates that pharmacologic intervention to enhance recovery may be possible in the subacute stage, days to weeks poststroke, after irreversible injury has occurred. This paper discusses the concept of "rehabilitation pharmacology" and reviews the growing literature from animal studies and pilot clinical trials on noradrenergic pharmacotherapy, a new experimental strategy in stroke rehabilitation. Amphetamine, a monoamine agonist that increases brain norepinephrine levels, is the most extensively studied drug shown to promote recovery of function in animal models of focal brain injury. Further research is needed to investigate the mechanisms and clinical efficacy of amphetamine and other novel therapeutic interventions on the recovery process.
Starting Page	97
Ending Page	105
Page Count	9
File Format	PDF HTM / HTML
Alternate Webpage(s)	https://www.cambridge.org/core/services/aop-cambridge-core/content/view/7128848C3F8A322D2F027A792AB2CBA2/S0317167100052173a.pdf/enhancing_recovery_after_stroke_with_noradrenergic_pharmacotherapy_a_new_frontier.pdf
PubMed reference number	10830340v1
Volume Number	27
Issue Number	2
Journal	The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques
Language	English
Access Restriction	Open
Subject Keyword	Acoustic Evoked Brain Stem Potentials Amphetamine Animal Model Aphasia Brain Injuries Brain Mapping Cerebral cortex Cerebrovascular accident Magnetic Resonance Imaging Natural History Neuroscience discipline Norepinephrine Patients Pharmacology Promotion (action) Review [Publication Type] Stroke Rehabilitation Subarachnoid Hemorrhage Transcranial magnetic stimulation Traumatic Brain Injury fMRI monoamine nervous system disorder therapeutic index
Content Type	Text
Resource Type	Article

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in