NDLI: Prognostic Value of PRAME Activity in Tumor Cells of Follicular Lymphoma

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Prognostic Value of PRAME Activity in Tumor Cells of Follicular Lymphoma

Content Provider	Semantic Scholar
Author	Misyurin, V. A. Misyurina, Ae Kravchenko, Sergey K. Lyzhko, N. A. Finashutina, YuP Kasatkina, Nn Mar’in, Ds Es, Nesterova Sharkunov, N. N. Baryshnikova, M. A. Misyurin, A. V.
Copyright Year	2019
Abstract	Aim. To set survival parameters for follicular lymphoma (FL) patients with diff erent PRAME expression levels in tumor cells. Materials & Methods. The study was conducted on samples of lymph nodes, blood, and bone marrow of 34 patients with newly diagnosed FL. PRAME expression levels were measured in tumor cells (centrocytes and centroblasts) by quantitative real-time PCR. The impact of diff erent PRAME expression levels on survival parameters was studied with median follow-up of 29 months. Clinical and laboratory characteristics used for FLIPI-1 and FLIPI-2 calculations in diff erent patient groups were compared. Results. A high (> 5 % against ABL control gene) PRAME expression level correlates with higher Ki-67 activity (p = 0.043) and larger tumor mass (p = 0.04). Survival parameters were worse with high PRAME expression level in FL cells. Combination of both high FLIPI-1/FLIPI-2 risk and high PRAME expression level determines extremely unfavorable prognosis and may result in death. Conclusion. In FL patients high PRAME expression level in tumor cells has negative prognostic value, but only in the presence of parameters determining high FLIPI-1 and FLIPI-2 risk. Juxtaposition of PRAME expression level and FLIPI-1/ FLIPI-2 values enables most reliable prediction of early mortality in FL patients.
Starting Page	173
Ending Page	178
Page Count	6
File Format	PDF HTM / HTML
DOI	10.21320/2500-2139-2019-12-2-173-178
Volume Number	12
Alternate Webpage(s)	http://bloodjournal.ru/wp-content/uploads/2019/03/7-1.pdf
Alternate Webpage(s)	https://doi.org/10.21320/2500-2139-2019-12-2-173-178
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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