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NF-κB Inhibitory Activities of Phenolic and Lignan Components from the Stems of Acanthopanax divaricatus var. albeofructus
| Content Provider | Semantic Scholar |
|---|---|
| Author | Song, Seok Bean Yang, Seo Young Kim, Young Ho |
| Copyright Year | 2015 |
| Abstract | − Acanthopanax divaricatus var. albeofructus (ADA) is commonly ingested as a traditional medicine or as a component of a health drink in Korea. In this phytochemical study, nine phenolics (1 9) and three lignans (10 12) were isolated from the MeOH extract of the stems of ADA. Chemical structures were elucidated by comparing spectroscopic data with reported values. Nuclear factor kappa B (NF-κB) inhibitory activity of the isolated compounds was evaluated using an NF-κB luciferase assay in HepG2 cells. Among them, compounds 1, 3 8, and 11 showed significant inhibitory effects on TNFα-induced NF-κB transcriptional activity in a dosedependent manner, with IC50 values ranging from 13.25 to 37.36 μM. Further studies on potential antiinflammatory effects and the benefits of phenolic and lignan components from ADA are warranted. |
| Starting Page | 232 |
| Ending Page | 236 |
| Page Count | 5 |
| File Format | PDF HTM / HTML |
| Volume Number | 20 |
| Alternate Webpage(s) | http://210.101.116.28/W_files/kiss2/05005279_pv.pdf |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
