Loading...
Please wait, while we are loading the content...
Similar Documents
Age-Dependency of Cardiac Troponin I in the Prediction of Right Ventricular Dysfunction in Normotensive Pulmonary Embolism
| Content Provider | Semantic Scholar |
|---|---|
| Author | Keller, Karsten Coldewey, Meike Geyer, Martin Beule, Johannes Balzer, Jörn Oliver Dippold, Wolfgang G. |
| Copyright Year | 2015 |
| Abstract | Aim: Right ventricular dysfunction (RVD) and cardiac troponin are important tools for accurate risk stratification in acute pulmonary embolism (PE). We aimed to investigate the impact of age on the effectiveness of cardiac Troponin I (cTnI) for predicting RVD and adverse outcomes in normotensive PE. Methods: A retrospective analysis of normotensive PE patients (2006-2011) was performed. Patients were subdivided in age groups of <70 years and ≥70 years, and their data was compared with the Mann-Whitney-U test. A logistic regression model for the association between cTnI>0.1 ng/ml and RVD was constructed. Age-dependent ROC curves with AUC and cut-off values were calculated for cTnI to predict RVD and cTnI to predict adverse outcomes as a combination of in-hospital death, pneumonia (on the basis of lung infarction) and RVD. Results: A total of 129 normotensive PE patients (59.7% women) were subdivided into groups of <70 years and ≥70 years (61 vs. 68 patients). The mean cTnI values of the <70 years and ≥70 years groups were similar (0.12±0.29 vs. 0.16±0.34 ng/ml, P=0.127). RVD was more frequent in the older group (82.4% vs. 55.7%, P=0.00106). In the logistic regression model, cTnI >0.1 ng/ml was associated with RVD (OR 4.00, CI95%: 1.23-13.04, P=0.0213). The AUC for cTnI predicting RVD was 0.76 in the younger age group and 0.84 in the older age group. The AUC for cTnI predicting adverse outcomes was 0.66 in the younger age group and 0.81 in the older age group. The cTnI cut-off values (0.005 vs. 0.015 ng/ml) for the identification of RVD and adverse outcomes (0.0050 vs. 0.0150 ng/ml) were slightly lower in younger than in older patients. Conclusions: The effectiveness of cTnI at predicting RVD as well as adverse outcomes is better in normotensive PE patients aged 70 years and older than in those younger than 70 years. |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | https://www.jscimedcentral.com/VascularMedicine/vascularmedicine-2-1021.pdf |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
