DHEA protects against visceral obesity and muscle insulin resistance in rats fed a high-fat diet.

Content Provider	Semantic Scholar
Author	Hansen, Polly A. Han, Dong Ho Nolte, Lorraine A. Chen, May W. Holloszy, John O.
Copyright Year	1997
Abstract	Visceral obesity is frequently associated with muscle insulin resistance. Rats fed a high-fat diet rapidly develop obesity and insulin resistance. Dehydroepiandrosterone (DHEA) has been reported to protect against the development of obesity. This study tested the hypothesis that DHEA protects against the increase in visceral fat and the development of muscle insulin resistance induced by a high-fat diet in rats. Feeding rats a diet providing 50% of the energy as fat for 4 wk resulted in a twofold greater visceral fat mass and a 50% lower rate of maximally insulin-stimulated muscle 2-deoxyglucose (2-DG) uptake compared with controls. Rats fed the high-fat diet plus 0.3% DHEA were largely protected against the increase in visceral fat (+11.3 g in high fat vs. +2.9 g in high fat plus DHEA, compared with controls) and against the decrease in insulin-stimulated muscle 2-DG uptake (0.94 ± 0.15 μmol ⋅ ml-1 ⋅ 20 min-1, controls; 0.46 ± 0.06 μmol ⋅ ml-1 ⋅ 20 min-1, high-fat diet; 0.78 ± 0.07 μmol ⋅ ml-1 ⋅ 20 min-1, high fat + DHEA). DHEA did not affect food intake. These results show that DHEA has a protective effect against accumulation of visceral fat and development of muscle insulin resistance in rats fed a high-fat diet.
Starting Page	R1704
Ending Page	R1708
Page Count	5
File Format	PDF HTM / HTML
DOI	10.1152/ajpregu.1997.273.5.R1704
PubMed reference number	29586549
Journal	Medline
Volume Number	273
Issue Number	5
Alternate Webpage(s)	http://ajpregu.physiology.org/content/ajpregu/273/5/R1704.full.pdf
Alternate Webpage(s)	https://doi.org/10.1152/ajpregu.1997.273.5.R1704
Journal	American journal of physiology. Regulatory, integrative and comparative physiology
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article