NDLI: Exploring ncRNAs in Alzheimer’s disease by miRMaster

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Exploring ncRNAs in Alzheimer’s disease by miRMaster

Content Provider	Semantic Scholar
Author	Fehlmann, Tobias Meese, Eckart Keller, Andreas
Copyright Year	2017
Abstract	Circulating biomarkers for the diagnosis of Alzheimer’s Disease (AD) such as amyloid-β levels are already applied in clinical care. New markers, especially marker panels that can be measured from blood and specifically focusing at early diagnosis, are under development [1]. Previously, we published miRNA signatures in Alzheimer’s Disease that have been discovered by high-throughput sequencing (also denoted as next-generation sequencing, NGS) [2, 3]. These studies focused on the quantification of known human miRNAs. Sequencing the fraction of all small RNAs in a specimen, however, allows not only for investigating canonical miRNAs but also enables prediction of new miRNAs, isoforms of miRNAs and even provides first insights in other RNA types. We developed a tool for the comprehensive analysis of small non-coding RNAs, primary miRNAs, starting from NGS raw data. Our web-based program miRMaster is free for academic users: www.ccb.uni-saarland.de/ mirmaster. Beyond the core functionality of analyzing known miRNAs, predicting isomiRs, discovery of mutations in miRNAs and identifying new miRNAs, we
Starting Page	3771
Ending Page	3772
Page Count	2
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&op=download&page=article&path%5B%5D=14054&path%5B%5D=44809
PubMed reference number	28030833v1
Alternate Webpage(s)	https://doi.org/10.18632/oncotarget.14054
DOI	10.18632/oncotarget.14054
Journal	Oncotarget
Volume Number	8
Language	English
Access Restriction	Open
Subject Keyword	Alzheimer's Disease Biological Markers Biopolymer Sequencing CDISC SEND Biospecimens Terminology Massively-Parallel Sequencing MicroRNAs Mutation Protein Isoforms Quantitation RNA Scientific Publication
Content Type	Text
Resource Type	Article

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