Differential cytokine changes in myasthenia gravis patients with antibodies against AChR and Musk

Content Provider	Semantic Scholar
Author	Yılmaz, Vuslat Oflazer, Piraye Serdaroğlu Aysal, Fikret Durmuş, Hacer Saruhan-Direskeneli, Guher
Copyright Year	2014
Abstract	presence of UO126. EPE peptide led to inhibition of proliferation in Th17 cells only at higher concentrations. The production of IL-17 was reduced with UO126, yet not affected by the EPE peptide. Interestingly, granulocyte–macrophage colony-stimulating factor (GM-CSF), a cytokine influencing the encephalitogenicity of Th17 cells, was diminished after treatment with EPE or UO126. We observed an increase in intracellular ERK phosphorylation in CD4 T cells in the course of Th17 differentiation. We are currently testing whether the inhibitory peptide EPE affects EAE disease outcome in a T cell adoptive transfer model. Taken together, our findings indicate that ERK translocation promotes encephalitogenicity in T cells by facilitating GM-CSF production.
Starting Page	212
Ending Page	213
Page Count	2
File Format	PDF HTM / HTML
DOI	10.1016/j.jneuroim.2014.08.571
Volume Number	275
Alternate Webpage(s)	https://api.elsevier.com/content/article/pii/S0165572814008042
Alternate Webpage(s)	https://www.sciencedirect.com/science/article/pii/S0165572814008042?dgcid=api_sd_search-api-endpoint
Alternate Webpage(s)	https://doi.org/10.1016/j.jneuroim.2014.08.571
Journal	Journal of Neuroimmunology
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article