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Use of endoscopic ultrasound in diagnosing plasmacytoma of the pancreas.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Miljkovic', Milos Senadhi, Viplove |
| Copyright Year | 2012 |
| Abstract | CONTEXT An extramedullary plasmacytoma is a discrete collection of monoclonal plasmocytes arising in tissues other than the bone. Gastrointestinal involvement has been reported in approximately 10% of cases and usually involves the liver; however, there have been a number of cases involving the pancreas. DISCUSSION Although helical CT can be used to diagnose pancreatic plasmacytomas based on a typical radiological appearance, there are a number of pitfalls with CT including similar radiologic appearances of other pancreatic tumors, malignant seeding induced by CT biopsy, and creation of multiple secondary plasmacytomas precipitated by CT biopsy. Tissue diagnosis is critical to management in pancreatic lesions as the decision to pursue surgery (pancreatic adenocarcinoma) versus chemotherapy (lymphoma) or radiation (extramedullary plasmacytoma) is dependent on a correct tissue diagnosis. Tissue diagnosis can change morbidity and mortality with respect to specific treatment of pancreatic lesions in the milieu of pancreatic tumor variance. In the confirmed tissue diagnosis of pancreatic plasmacytoma, radiation and chemotherapy can be preferentially chosen over high risk surgery. EUS-FNA has a lower risk of malignant seeding, complications, and a high sensitivity in the diagnosis of pancreatic plasmacytomas, especially with an increased number of passes and bedside cytopathologists. CONCLUSION It is important for physicians to have a high index of suspicion for diagnosing pancreatic plasmacytomas in the appropriate clinical setting (i.e., a previously diagnosed multiple myeloma, extramedullary plasmacytoma or any other plasma cell neoplasm). EUS-FNA is now an indispensable imaging modality to achieve the diagnosis of pancreatic extramedullary plasmacytomas with an inherently lower rate of complications, and should be the first choice for tissue evaluation. |
| Starting Page | 1025 |
| Ending Page | 1032 |
| Page Count | 8 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://pancreas.imedpub.com/use-of-endoscopic-ultrasound-in-diagnosing-plasmacytoma-of-the-pancreas.pdf |
| Alternate Webpage(s) | http://www.joplink.net/prev/201111/014580.pdf |
| Alternate Webpage(s) | http://www.serena.unina.it/index.php/jop/article/download/urn:nbn:it:unina-3435/726 |
| PubMed reference number | 22233943v1 |
| Volume Number | 13 |
| Issue Number | 1 |
| Journal | JOP : Journal of the pancreas |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Biliopancreatic Diversion Body tissue Bone Tissue Endoscopic Ultrasound Entity Class - imaging modality Extramedullary Plasmacytoma Fine needle aspiration biopsy Lymphoma Malignant Childhood Central Nervous System Neoplasm Morbidity - disease rate Multiple Myeloma Neoplasms Pancreas extract Pancreatic Neoplasm Pancreatic adenocarcinoma Plasma Cell Neoplasm Plasma Cells Sample Variance Seeding Structure of delta Cell of islet X-Ray Computed Tomography |
| Content Type | Text |
| Resource Type | Article |
