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Discordancia de defectos congénitos en recién nacidos de embarazos múltiples en el Instituto Nacional de Perinatología
| Content Provider | Semantic Scholar |
|---|---|
| Author | López-Uriarte, Arelí Aguinaga-Ríos, Mónica |
| Copyright Year | 2012 |
| Abstract | Introduccion: Los embarazos gemelares representan menos del 3% de los recien nacidos; sin embargo, constituyen el 12% de las muertes perinatales. Presentan una alta frecuencia de complicaciones que se clasifican en: propias del embarazo gemelar, defectos congenitos aislados y anomalias cromosomicas. Material y metodos: Se revisaron los expedientes clinicos de los recien nacidos en embarazos multiples que recibieron interconsulta por el Departamento de Genetica del INPer de enero de 2009 a septiembre de 2011. Se incluyeron 76 casos; 56 fueron de embarazos dobles y 20 de triples. Resultados: Se registraron 619 recien nacidos de embarazos multiples; 76 fueron valorados por genetica, lo que corresponde al 12.2% de los embarazos multiples con defectos, los cuales fueron: a) En los gemelares dobles: tres deformaciones, siete disrupciones, nueve malformaciones, 10 anomalias propias de gemelos (dos fetos acardicos), cuatro sindromes (Holt-Oram y espectro facio-auriculo-vertebral y dos con sindrome de Down), tres defectos menores y 20 recien nacidos sanos. b) En los triples: una deformacion, una malformacion, tres sindromes (Walker-Warburg, Goldenhar y Down), tres anomalias propias de gemelos (toracoonfalopagos) y un sindrome de Down, tres con defectos menores y nueve recien nacidos sanos. Conclusiones: Los defectos congenitos encontrados en este estudio son similares a lo reportado en la literatura mundial. Observamos discordancia en presentacion y severidad en defectos congenitos de todos los gemelos, siendo mayor en los monocoriales. Varios procesos durante la division de un ovulo fertilizado pueden predisponer al desarrollo de una anomalia congenita, o bien presentarse como resultado de una alteracion en la placenta. Introduction: Twin pregnancies represent less than 3% of newborns and up to 12% of perinatal deaths, with a high frequency of complications such as: characteristic of twin pregnancy, isolated birth defects and chromosomal abnormalities. Materials and methods: We reviewed the clinical records of newborns from multiple pregnancies evaluated by the Genetics Department at INPer between January 2009 and September 2011. We included 76 cases, 56 were twin pregnancies and 20 triplets. Results: There were 619 infants of multiple pregnancies, 76 were assessed by a geneticist, corresponding to 12.2% of multiple pregnancies with congenital defects, which were: a) In twins: three deformations, seven disruptions, nine birth defects, 10 defects characteristic of multiple gestation (two acardic fetuses), four syndromes (Holt-Oram and oculo auriculo vertebral spectrum and two Down syndrome), three minor defects and 20 healthy neonates. b) In triplets: one deformation, one malformation, three syndromes (Walker-Warburg, Goldenhar and Down), three defects of twins (thoracopagus), three minor defects and nine healthy neonates. Conclusions: Birth defects found in this study are similar to those reported in the world literature. We observed discordance in the presence and severity of congenital defects in all the twins studied, this observation was higher in monochorionic pairs. Several processes in the division of a fertilized egg may predispose to the development of a congenital abnormality, or it can result as an alteration in the placenta. |
| Starting Page | 8 |
| Ending Page | 16 |
| Page Count | 9 |
| File Format | PDF HTM / HTML |
| Volume Number | 26 |
| Alternate Webpage(s) | http://www.scielo.org.mx/pdf/prh/v26n1/v26n1a2.pdf |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
