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The Effect of Tranexamic Acid on Blood Loss during Total Knee Arthroplasty
| Content Provider | Semantic Scholar |
|---|---|
| Author | Surannavar, Jagadish Harsharaj, K. Rajesh Kashyap. S. Nazareth, Edward |
| Copyright Year | 2014 |
| Abstract | Background: Tranexamic acid is antifibrinolytic drug which has the property to reduce intraoperative and postoperative bleeding. There are several studies supporting the use of tranexamic acid in total knee joint replacements and few in total hip replacements. This study was intended to establish the effects of tranexamic acid in minimizing the intra operative and post operative blood loss in total knee arthroplasty. Material and methods: This was a prospective follow up study conducted in Father Muller Medical College , Mangalore over period of 4 months from August 2013 to November 2013. A total number of 30 patients who underwent total knee arthroplasty were included for this study. The patients were grouped as treatment and control group. The treatment group and control group were selected by purposive sampling. In the treatment group, the patients undergoing total knee arthroplasty received single dose of intravenous tranexamic acid 10mg/kg body weight 5 minutes before skin incision and equal volume of saline was injected in the control group. Intra operative blood loss was calculated by galvanometric method 20 , weighing the sponges used and soiled by blood during surgery and measuring the amount of blood collected in suction apparatus used during the surgery. The haemoglobin level assessed post operatively and compared with preoperative haemoglobin level. The amount of fluid collected in the post-operative drain were also measured. All the collected data are analyzed with Fisher exact test. Conclusion:Tranexamic acid administrated before surgical incision is efficient in reducing bleeding during common surgeries around the hip joint. Especially surgery where more amount of blood loss was expected, like total joint replacement and hemiarthroplasty, the drug had shown significant benefit compared with the control group. |
| Starting Page | 85 |
| Ending Page | 88 |
| Page Count | 4 |
| File Format | PDF HTM / HTML |
| DOI | 10.9790/0853-13548588 |
| Volume Number | 13 |
| Alternate Webpage(s) | http://www.iosrjournals.org/iosr-jdms/papers/Vol13-issue5/Version-4/R013548588.pdf |
| Alternate Webpage(s) | https://doi.org/10.9790/0853-13548588 |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
