NDLI: Inhibition shapes sex selectivity in the mouse accessory olfactory bulb.

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Inhibition shapes sex selectivity in the mouse accessory olfactory bulb.

Content Provider	Semantic Scholar
Author	Hendrickson, Rebecca C. Krauthamer, Sandra Essenberg, James M. Holy, Timothy E.
Copyright Year	2008
Abstract	Laterally connected inhibitory circuitry is found throughout the nervous system, including many early sensory processing systems. The extent to which it plays a role in shaping neuronal stimulus selectivity in systems like olfaction, however, which lack a simple two-dimensional representation of their stimulus space, has remained controversial. We examined this issue using an experimental preparation that allowed electrophysiological recording from the accessory olfactory bulb of an anesthetized mouse during the controlled delivery of pheromonal stimuli, in this case derived from the urine of male and female mice. We found that individual neurons were often highly selective for the sex of the urine donor. Examination of both explicitly inhibitory responses, as well as responses to mixtures of male and female urine, revealed that laterally connected inhibition was both prevalent and of large magnitude, particularly for male-selective neurons. Pharmacological manipulation of this inhibition resulted in a shift in many neurons' stimulus selectivities. Finally, we found that a behavioral response (pregnancy block) evoked by the presence of unfamiliar male urine could be suppressed by the addition of female urine to the stimulus, demonstrating that this system displays a behavioral opponency consistent with neural inhibition. Together, these results indicate that laterally connected inhibitory circuitry in the accessory olfactory bulb plays an important role in shaping neural selectivity for natural stimuli.
Starting Page	1131
Ending Page	1133
Page Count	3
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://www.jneurosci.org/content/jneuro/28/47/12523.full.pdf
PubMed reference number	19020044v1
Alternate Webpage(s)	https://doi.org/10.1523/JNEUROSCI.2715-08.2008
DOI	10.1523/jneurosci.2715-08.2008
Journal	The Journal of neuroscience : the official journal of the Society for Neuroscience
Volume Number	28
Issue Number	47
Language	English
Access Restriction	Open
Subject Keyword	CNS disorder Neural Inhibition Neurons Pharmacology Sensory Process Smell Perception Structure of olfactory bulb
Content Type	Text
Resource Type	Article

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