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2 Hypertension July 2014 Methods For detailed Methods , see online-only Data Supplement . Generation of Endothelial Cell – Targeted GCH 1 Knockout Mice
| Content Provider | Semantic Scholar |
|---|---|
| Author | Chuaiphichai, Surawee McNeill, Eileen Douglas, Gillian Crabtree, Mark J. Bendall, Jennifer K. Hale, Ashley B. Alp, Nicholas J. Channon, Keith M. |
| Abstract | T etrahydrobiopterin (BH4) is an essential cofactor for the nitric oxide synthase (NOS) enzymes. 1 When BH4 availability is limiting, NO generation becomes uncoupled from l-arginine oxidation, resulting in superoxide radical (O 2 • –) rather than NO production. 1 Substantial evidence suggests that reduced vascular BH4 bioavailability contributes to the pathogenesis of endothelial dysfunction. 1 For example, BH4 levels in vascular tissue from diabetic mice, apolipoprotein E knockout mice hyper-cholesterolemic rabbits, and patients with diabetes mellitus are significantly reduced and associated with reduced NO-mediated endothelial function. |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://hyper.ahajournals.org/content/hypertensionaha/early/2014/04/28/HYPERTENSIONAHA.114.03089.full.pdf |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
