NDLI: Exposition aux pesticides et risque de diabète de type 2 : une étude au nord du Bénin (Afrique de l'Ouest)

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Exposition aux pesticides et risque de diabète de type 2 : une étude au nord du Bénin (Afrique de l'Ouest)

Content Provider	Semantic Scholar
Author	Azandjeme, Colette Sylvie
Copyright Year	2015
Abstract	Objectives: High pesticide use as observed in certain parts of Africa may be detrimental to health. We examined overall (OVO) and abdominal obesity (ABO) according to serum levels of organochlorine pesticides (OC) in persons living with type-2 diabetes and control subjects. Methods: In a case-control study, 106 diabetic adults were paired with 106 euglycemic subjects by age, gender, ethnic group and residence area. Serum concentrations of four detected OCs were measured in 116 men and 96 women by gas chromatography coupled to mass spectrometry: p,p’-DDT, p,p’-DDE, beta-hexachlorohexane and trans-nonachlor. Three criteria were used for ABO: 1) metabolic syndrome criterion of waist circumference (WC) of 80 cm for men and 94 cm for women; 2) the suggested cut-off for African subjects of 86 cm for men and 92 cm for women; 3) WC/height ratio above 0.5. BMI ≥ 30 defines OVO. Fat mass (FM) based on bioelectrical impedance and Sun formula was considered high when above 0.25 for men and 0.33 for women. Socioeconomic status (SES) was computed based on household assets, education level and occupation. Results: High FM (28.8%) and ABO (60.4%) affect more diabetic than non-diabetic subjects (except for OVO), more women than men, and wealthier than lower SES individuals. When the 3rd tertile of OC level was compared with the 1st tertile, ABO was consistently associated with all four OCs. The association with OVO and high FM was less consistent. According to logistic regression, ABO was associated with a two to fourfold increase in OC levels after adjusting for diabetes status, gender and SES. The WC/H ratio showed the best sensitivity (0.69), specificity (0.54) and area under the curve (0.57) among ABO criteria.
File Format	PDF HTM / HTML
Alternate Webpage(s)	https://papyrus.bib.umontreal.ca/xmlui/bitstream/handle/1866/11836/Azandjeme_Colette_Sylvie_2014_These.pdf?isAllowed=y&sequence=6
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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