Clinical significance of different antiphospholipid antibodies in the WAPS (warfarin in the antiphospholipid syndrome) study.

Content Provider	Semantic Scholar
Author	Galli, Monica Borrelli, Giovanna Jacobsen, Eva Marie Marfisi, Rosa Maria Finazzi, Guido Marchioli, Roberto Wisloff, Finn Marziali, Stefana Morboeuf, Olivier Barbui, Tiziano
Copyright Year	2007
Abstract	To assess the clinical significance of lupus anticoagulants (LAs) and antiphospholipid antibodies (aPLs) toward thrombosis and abortions, we measured them in 112 patients whose samples were available at enrollment in the warfarin in the antiphospholipid syndrome (WAPS) study. Enzyme-linked immunosorbent assay (ELISA) and coagulation test values in the highest and lowest tertiles were compared. When considered separately, IgG antibodies to beta2-glycoprotein I (abeta2GPI) and prothrombin (aPT) were associated with anamnestic arterial and venous thrombosis, respectively, and those to annexin AV (aAnAV) with abortions. IgM antibodies to protein S and the lupus ratio of the dilute prothrombin time were associated with prospective thrombosis. No other association for IgM antibodies was seen. LA-positive patients who carried abeta2GPI antibodies were at risk of anamnestic arterial and total thrombosis and aPT antibodies to that of anamnestic venous and total thrombosis. LA-positive patients who carried IgG abeta2GPI and aAnAV antibodies were at risk for both anamnestic abortion and prospective thrombosis. Overall, these data support the inclusion of abeta2GPI antibodies in and suggest the removal of anticardiolipin antibodies from the laboratory criteria of the antiphospholipid syndrome. They also suggest that the measurement of aPT and aAnAV antibodies is useful in some selected situations and that there is little role for IgM antibody detection.
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Alternate Webpage(s)	http://www.bloodjournal.org/content/bloodjournal/110/4/1178.full.pdf?sso-checked=true
Alternate Webpage(s)	http://www.bloodjournal.org/content/bloodjournal/early/2007/04/17/blood-2007-01-066043.full.pdf?sso-checked=true
PubMed reference number	17440049v1
Volume Number	110
Issue Number	4
Journal	Blood
Language	English
Access Restriction	Open
Subject Keyword	Annexins Antibodies, Anticardiolipin Anticoagulants Antiphospholipid Antibodies Antiphospholipid Syndrome Atrioventricular Block Enzyme-Linked Immunosorbent Assay Induced abortion (procedure) Lactic acid Lupus Erythematosus, Systemic Patients Prothrombin time assay Venous Thrombosis Warfarin X-Linked Combined Immunodeficiency Diseases
Content Type	Text
Resource Type	Article