NDLI: The glycoprotein of viral hemorrhagic septicemia virus (VHSV): antigenicity and role in virulence.

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The glycoprotein of viral hemorrhagic septicemia virus (VHSV): antigenicity and role in virulence.

Content Provider	Semantic Scholar
Author	Béarzotti, Monique Monnier, A. F. Vende, Patrice Grosclaude, Jeanne Kinkelin, P. De Benmansour, Abdenour
Copyright Year	1995
Abstract	In order to study the antigenic structure of the G protein of VHSV, we produced several anti-G monoclonal antibodies (MAbs) and used 4 neutralizing MAbs (NMAbs) to select resistant (MAR) mutants. Each MAR mutant was confronted with the 4 NMAbs in a neutralization test, and also with our panel of MAbs in surface plasmon resonance (SPR) analysis to determine the extent of their relatedness. Determination of the sequence of the entire G gene of representative MAR mutants allowed us to map the mutations responsible for the resistant phenotypes. We identified several locations on the G protein sequence, which represent, most probably, critical positions within the binding sites of the neutralizing MAbs. In addition, the MAR mutants selected with a cross-reactive MAb exhibited a reduced pathogenicity for fish. This indicated that the regions bearing the point mutations selected with MAb C10 were probably involved in the determination of the virulent phenotype.
File Format	PDF HTM / HTML
PubMed reference number	8581015
Journal	Medline
Volume Number	26
Issue Number	5-6
Alternate Webpage(s)	https://hal.archives-ouvertes.fr/hal-00902367/document
Journal	Veterinary research
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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