NDLI: Peroxisome proliferator-activated receptors: Targets for the treatment of metabolic illnesses (Review).

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Peroxisome proliferator-activated receptors: Targets for the treatment of metabolic illnesses (Review).

Content Provider	Semantic Scholar
Author	Moore-Carrasco, Rodrigo Bustamante, Mauricio Poblete Guerra, Oscar González Madariaga, Elba Leiva Escudero, Veronica Mujica Arellano, Claudio Aranguez
Copyright Year	2008
Abstract	Peroxisome proliferator-activated receptors (PPARs) belong to a family of transcription factors of which three isotypes, PPARα, PPARδ (β) and PPARγ, are known. These play a central role in regulating intermediate metabolism and in incidences of inflammation. In recent years, a greater understanding of their mechanisms of action and their effects, principally in the management of cardiovascular disease, has been achieved. PPAR agonists, catalysts and agents have been used since the 1990s, when it was confirmed that fibrates possess lipid modifying properties when selectively activating PPARα. In addition, thiazolidinediones, structures analogous to fibrates, showed PPARγ activity with an insulin-sensitizing effect, leading to their use in the control and even prevention of diabetes mellitus type 2. Currently, studies are oriented to the development of agents that activate multiple PPAR isoforms - not only dual (PPARα/γ), but also PPAR panagonists (α/γ/δ). The purpose of this review is to explain the mechanisms of the molecular action and the effects of PPAR agonists, and also to analyze existing and current studies concerning their use in cardiovascular and metabolic illnesses.
File Format	PDF HTM / HTML
Alternate Webpage(s)	https://www.spandidos-publications.com/mmr/1/3/317/download
PubMed reference number	21479412v1
Volume Number	1
Issue Number	3
Journal	Molecular medicine reports
Language	English
Access Restriction	Open
Subject Keyword	Activation action Brain Diseases, Metabolic Cardiovascular Diseases Diabetes Mellitus Diabetes Mellitus, Non-Insulin-Dependent Dual Fibrates, lipid modifying drugs, plain Illness (finding) Immunoglobulin Isotypes Metabolic Diseases Metabolic Process, Cellular Peroxisome Proliferator-Activated Receptors Peroxisome Proliferator-activated Receptor alpha Agonists [MoA] Peroxisome Proliferators Protein Isoforms TRANSCRIPTION FACTOR Thiazolidinediones
Content Type	Text
Resource Type	Article

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