Influence of aldosterone on sodium, water and potassium metabolism in chronic renal disease.

Content Provider	Semantic Scholar
Author	Schrier, Robert Regal, E. M.
Copyright Year	1972
Abstract	Influence of aldosterone on sodium, water and potassium metabolism in chronic renal disease. To evaluate the physiological importance of aldosterone in chronic renal disease, ii studies were performed in nine patients with renal impairment of varying etiology and severity during periods of normal and low sodium intake. Decreased sodium excretion during sodium restriction was accompanied by increased aldosterone excretion and this anti-natriuretic effect could be reversed by the administration of spironolactone. Constancy of urinary potassium excretion occurred during the period of sodium restriction and may have been related to a combination of diminished distal sodium delivery and increased aldosterone activity. Sodium restriction was also associated with a diminution in renal concentrating capacity and an improvement in renal diluting capacity. Only the improvement in renal diluting capacity, as judged by the minimal urinary osmolality achieved during an acute water load, could be reversed by the administration of spironolactone. These results thus suggest that aldosterone is of physiological importance to the control of urinary sodium, potassium and water excretion in patients with chronic renal disease.
File Format	PDF HTM / HTML
Alternate Webpage(s)	https://core.ac.uk/download/pdf/81950153.pdf
PubMed reference number	4671219v1
Volume Number	1
Issue Number	3
Journal	Kidney international
Language	English
Access Restriction	Open
Subject Keyword	Aldosterone Chronic Kidney Diseases Dietary Potassium Hyperaldosteronism Low sodium diet Patients Renal Insufficiency Sodium, Dietary Spironolactone natriuretic
Content Type	Text
Resource Type	Article