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Le rôle des cellules gliales de Müller dans la mort des cellules ganglionnaires de la rétine par des mécanismes cellulaires non-autonomes
| Content Provider | Semantic Scholar |
|---|---|
| Author | Lebrun-Julien, Frédéric |
| Copyright Year | 2010 |
| Abstract | A hallmark of glaucomatous optic nerve damage is retinal ganglion cell (RGC) death. RGCs, like other central nervous system neurons, have a limited capacity to survive or regenerate an axon following injury. Strategies that prevent or slow down RGC degeneration, in combination with intraocular pressure management, may be beneficial to preserve vision in glaucoma. Recent progress in neurobiological research has led to a better understanding of the molecular pathways that regulate the survival of injured RGCs. Here we discuss a variety of experimental strategies including intraocular delivery of neuroprotective molecules, viral-mediated gene transfer, cell implants and stem cell therapies, which share the ultimate goal of promoting RGC survival following optic nerve damage. The challenge now is to assess how this wealth of knowledge can be translated into viable therapies for the treatment of glaucoma and other optic neuropathies. |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | https://papyrus.bib.umontreal.ca/xmlui/bitstream/handle/1866/3780/Lebrun-Julien_Frederic_2010_these.pdf;jsessionid=E1A2D7A3D544568F513D6E3DEEF45DE0?sequence=4 |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
