Intestinal disaccharidase deficiency in children with coeliac disease.

Content Provider	Semantic Scholar
Author	Arthur, A. B.
Copyright Year	1966
Abstract	In a recent paper on their experiences with intestinal biopsy in children with coeliac disease, Sheldon and Tempany (1966) included evidence of a reduction in disaccharidase activity in many of the biopsies, thus confirming recently published observations (Plotkin and Isselbacher, 1964; Shmerling, Auricchio, Rubino, Hadorn, and Prader, 1964; Nordio, Lamedica, Vignolo, and Berio, 1965; Lifshitz, Klotz, and Holman, 1965). In the present study certain aspects of the quantitative method of Plotkin and Isselbacher (1964) for estimation of disaccharidase activity have been investigated more fully. Disaccharidase activities were assayed, using a slight modification of their method, and histological examination of duodenal or jejunal mucosa was carried out in children who were suffering from coeliac disease (both treated and untreated) and they were compared with the findings in a group of children suffering from miscellaneous conditions resulting in malabsorption, and in a group with normal small intestinal mucosae. Enzyme studies were also carried out in one case using necropsy material. The methods and results in this case are discussed separately.
File Format	PDF HTM / HTML
DOI	10.1136/adc.41.219.519
PubMed reference number	5957725
Journal	Medline
Volume Number	41
Issue Number	219
Alternate Webpage(s)	http://adc.bmj.com/content/archdischild/41/219/519.full.pdf
Alternate Webpage(s)	https://doi.org/10.1136/adc.41.219.519
Journal	Archives of disease in childhood
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article