NDLI: Protective effect of ischemia preconditioning on ischemia-reperfusion injury in rat liver transplantation.

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Protective effect of ischemia preconditioning on ischemia-reperfusion injury in rat liver transplantation.

Content Provider	Semantic Scholar
Author	Qing, Zhou Zhang, X. S. Gao, Chang-Xing Xia, Tianfang Wu, Kaiming Pang, Liming
Copyright Year	2015
Abstract	We explored the protective effect of ischemia preconditioning (IP) on ischemia-reperfusion injury in rat liver transplantation. An orthotopic liver transplantation model was utilized in the study. A total of 54 Sprague-Dawley rats were divided into a control group (group A, no liver transplantation), liver transplantation group (group B, heparin Ringer's lactate solution was perfused via the portal vein before donor liver collection), and liver transplantation with IP group (group C, IP was performed for different time periods before donor liver collection). Liver function, B-cell lymphoma 2 expression in hepatic cells, cell apoptosis, and cellular ultrastructure changes were detected after surgery. After surgery, serum alanine aminotransferase activity was significantly higher in group B than in group A, while it was not clearly enhanced in group C and decreased progressively with increasing cycles of IP as bile capacity gradually increased. Compared with group B, group C showed alleviated injury of hepatic cells, increased B-cell lymphoma 2 expression, and a lower apoptosis index. IP had a protective effect on ischemia-reperfusion injury in rat liver transplantation, and the mechanism correlated with increased B-cell lymphoma 2 expression in hepatic cells and inhibition of cell apoptosis.
File Format	PDF HTM / HTML
DOI	10.4238/2015.April.10.12
PubMed reference number	25966066
Journal	Medline
Volume Number	14
Issue Number	2
Alternate Webpage(s)	http://www.funpecrp.com.br/gmr/year2015/vol14-2/pdf/gmr4600.pdf
Alternate Webpage(s)	https://doi.org/10.4238/2015.April.10.12
Journal	Genetics and molecular research : GMR
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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