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Factores que predicen el fracaso de las interrupciones del tratamiento antirretroviral (TAR) en los pacientes con infección por el VIH
| Content Provider | Semantic Scholar |
|---|---|
| Author | Jiménez, Miguel Cervero Perea, Rafael Torres Capillas, Juan José Ruiz |
| Copyright Year | 2005 |
| Abstract | INTRODUCTION. Treatment interruptions may be an alternative to HAART in the management of chronically infected HIV-patients. We designed this study in an attempt to assess the predictability of this strategy. METHODS. We recruited HIV-infected patients whose treatment had been suspended. Interruption was due to the patient’s own decision, or toxicity, or because the patient had started the treatment with more than 350 CD4 cells/ L (immunologic criteria). RESULTS. Forty-one consecutive patients were included, with a median follow-up of 13 months. Failure was associated with the reason for interruption (p 0.0063). Failure occurred in 14.3% of those who interrupted treatment due to immunological criteria and in 40% of those who interrupted treatment due to their own decision or toxicity. The reasons for interruption were: toxicity in 11 patients (26.8%), personal decision in 9 (21.9%) and immunological criteria in 21 (51.2%). In the univariate analysis, the nadir CD4 cell count < 350 cél./ L [OR 16 (p 0.054)] was statistically significant in the patients who stopped treatment due to immunological criteria, while treatment with protease inhibitors [OR 14 (p 0.032)] was statistically significant in the remaining patients. In the multivariable analysis only nadir CD4 < 350 cél./ L was independently related with failure. CONCLUSIONS. Failure was related to interruption criteria and was greater in patients who stopped due their own decision or toxicity. When interruption was due to immunological criteria, the factor predicting failure was nadir CD4 cell count < 350 cél./ L. In the remaining patients, none of the variables was related to failure. |
| Starting Page | 202 |
| Ending Page | 204 |
| Page Count | 3 |
| File Format | PDF HTM / HTML |
| Volume Number | 23 |
| Alternate Webpage(s) | https://www.elsevier.es/index.php?p=revista&pRevista=pdf-simple&pii=13073145 |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
