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Serum placental growth factor and soluble fms‐like tyrosine kinase 1 at mid‐gestation in healthy women: Association with small‐for‐gestational‐age neonates
| Content Provider | Semantic Scholar |
|---|---|
| Author | Furuta, Itsuko Umazume, Takeshi Kojima, Takashi Chiba, Kentaro Nakagawa, Kinuko Hosokawa, Ami Ishikawa, Satoshi Yamada, Takahiro Morikawa, Mamoru Minakami, Hisanori |
| Copyright Year | 2017 |
| Abstract | AIM This study was performed to determine the associations between serum placental growth factor (PlGF) and soluble fms-like tyrosine kinase 1 (sFlt-1) levels at mid-gestation with the risk of small-for-gestational-age (SGA) neonates born at gestational week (GW) ≥ 36 in healthy women. METHODS PlGF and sFlt-1 concentrations were determined at GW 24-27 in 183 women with births at GW ≥ 36, but without gestational diabetes mellitus and hypertension. RESULTS Thirteen (7.1%) SGA neonates were born. Median (range) GW at blood sampling was similar between women with and without SGA (25 [24-25] and 24 [24-27], respectively, P = 0.671). Pre-pregnancy body mass index (BMI) and PlGF levels were significantly lower in women with than without SGA, while sFlt-1 levels and sFlt-1 : PlGF ratio (sFlt-1/PlGF) did not differ significantly between the two groups. PlGF and sFlt-1/PlGF, but not BMI or sFlt-1, showed significant correlations with birthweight z-score; the correlation was positive for PlGF and negative for sFlt-1/PlGF. Women with PlGF level < 10th percentile and those with sFlt-1/PlGF level > 90th percentile showed significantly increased risk of SGA compared to those with respective counterpart characteristics; relative risk was 3.8 (95% confidence interval, 1.3-11.3; 21% [4/19] vs 5.5% [9/164]) for PlGF and 7.9 (95% confidence interval, 3.0-20.8, 33.3% [6/18] vs 4.2% [7/165]) for sFlt-1/PlGF. CONCLUSION Maternal PlGF and sFlt-1/PlGF determined during GW 24-27 were associated with the risk of SGA neonates born at GW ≥ 36, even in women with uncomplicated pregnancies. |
| Starting Page | 169 |
| Ending Page | 179 |
| Page Count | 11 |
| File Format | PDF HTM / HTML |
| DOI | 10.1111/jog.13340 |
| PubMed reference number | 28422347 |
| Journal | Medline |
| Volume Number | 43 |
| Alternate Webpage(s) | https://eprints.lib.hokudai.ac.jp/dspace/bitstream/2115/70897/1/JObstetGynaecolRes43_1152.pdf |
| Alternate Webpage(s) | https://doi.org/10.1111/jog.13340 |
| Journal | The journal of obstetrics and gynaecology research |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
