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Poly(vinyl alcohol) Scaffolds with Tailored Morphologies for Drug Delivery and Controlled Release
| Content Provider | Semantic Scholar |
|---|---|
| Author | Gutiérrez, María Concepción García-Carvajal, Zaira Yunuen Jobbágy, Matías Rubio, Fausto Yuste, Luís Rojo, Fernando Ferrer, María Luisa Monte, Francisco |
| Copyright Year | 2007 |
| Abstract | Poly(vinyl alcohol) (PVA) scaffolds are prepared by a cryogenic process that consists of the unidirectional freezing of a PVA solution. The scaffolds exhibit a microchanneled structure, the morphology of which (in terms of pore diameter, surface area, and thickness of matter accumulated between adjacent microchannels) can be finely tailored by the averaged molecular weight of PVA, the PVA concentration in the solution, and the freezing rate of the PVA solution. The resulting PVA scaffolds are suitable substrates for drug-delivery purposes, the drug release being controlled (from tens of minutes up to several days) by the morphology of the microchanneled structure. In vitro experiments reveal the efficiency of PVA scaffolds for controlling the release of ciprofloxacin into a bacteria culture medium. |
| Starting Page | 3505 |
| Ending Page | 3513 |
| Page Count | 9 |
| File Format | PDF HTM / HTML |
| DOI | 10.1002/adfm.200700093 |
| Volume Number | 17 |
| Alternate Webpage(s) | http://pdf-s3.xuebalib.com:1262/xuebalib.com.44055.pdf |
| Alternate Webpage(s) | https://doi.org/10.1002/adfm.200700093 |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |