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Comparison between intracytoplasmic sperm injection and in-vitro fertilization (IVF) with high insemination concentration after total fertilization failure in a previous IVF attempt.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Kastrop, Peter M. M. Weima, Sjerp M. Kooij, R. Van |
| Copyright Year | 1999 |
| Abstract | The aim of this prospective study was to evaluate whether couples with total fertilization failure in a previous in-vitro fertilization (IVF) attempt should be offered an additional IVF treatment with elevated insemination concentration or should be treated with intracytoplasmic sperm injection (ICSI). In 23 cycles 228 sibling metaphase II (MII) oocytes were randomly divided: 143 and 85 oocytes were utilized for ICSI and IVF respectively. Of the 143 injected (ICSI) oocytes, 90 (62.9%) were normally fertilized (two pronuclei), whereas 21 (14.7%) oocytes were damaged by the ICSI procedure. Of the fertilized oocytes 72 (80%) developed into transferable embryos. No fertilization at all was observed in the 85 sibling MII oocytes which were inseminated (P < 0.001). In all 23 cycles at least one embryo, obtained by ICSI, could be replaced. Eight pregnancies were achieved of which six resulted in the delivery of nine healthy children. In conclusion, for couples with no or almost no fertilization of oocytes in previous IVF attempts, ICSI appeared to be far superior to an additional IVF attempt with further elevated insemination concentrations. |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | https://oup.silverchair-cdn.com/oup/backfile/Content_public/Journal/humrep/14/1/10.1093_humrep_14.1.65/1/140065.PDF?Expires=1496181348&Key-Pair-Id=APKAIUCZBIA4LVPAVW3Q&Signature=B0E1aV9OaFmI78g8LrDwH2Y4C8jlsmz8PUb0VehVXFhElYWiQSVhKWuDRjrhClpzu9RRApYBJW1VqgO2GNfxp7P7J4JL~ypG9gjmDJy9KGHismIQm4y9B8jEpeWNg4oeqhLvdzT968HQtN0OSOXzO9mQovHUr9RxXg9x30F~xGMcYAATELKiN5IsYCftXzAC3K5qIYrgI~BoaiS~TLB5F2wIZoa5jEd8km-5zriC04uUDPq0iNxgFuvNURMI6oTvIse9Mjj4zl655dUAgpiPSCr~wWBhbK9TX8MATq4mWVGWRIj~A1dutapwLx1SpetmLFMPNizspHUPzubbvYJrwA__ |
| PubMed reference number | 10374096v1 |
| Volume Number | 14 |
| Issue Number | 1 |
| Journal | Human reproduction |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Artificial Insemination Eighty Embryo Fertilization Liver Failure, Acute Mitotic Metaphase Pregnancy Sperm Injections, Intracytoplasmic Spermatozoa Cell Count |
| Content Type | Text |
| Resource Type | Article |
