NDLI: Combined electroconvulsive therapy and clozapine in treatment -resistant schizophrenia

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Combined electroconvulsive therapy and clozapine in treatment -resistant schizophrenia

Content Provider	Semantic Scholar
Author	Kales, Helen C. Dequardo, John R. Tandon, Rajiv
Copyright Year	1999
Abstract	1. To assess the efficacy and safety of combining electroconvulsive therapy (ECT) and clozapine in patients with treatment-resistant schizophrenia, the authors reviewed use of this combination in four treatment-resistant schizophrenic inpatients and one inpatient with schizophrenia who was intolerant of clozapine doses needed to control her psychosis. 2. The combination of clozapine and bilateral ECT was modestly effective in two treatment-resistant patients and markedly effective in three patients. There was significant overall improvement in patients' Clinical Global Impression (CGI) and Global Assessment of Functioning (GAF) scores (p < 0.005 and p < 0.0004, respectively), however in patients where marked symptomatic improvement was noted, effects were not sustained. 3. One of the patients that showed dramatic yet transient improvement followed by relapses received maintenance ECT but relapsed despite this. 4. The authors saw no adverse effects in connection with the combination of ECT and clozapine. 5. Supplementing clozapine with a course of bilateral ECT appears to be safe and is effective in some patients with refractory schizophrenia, however its beneficial effects may be short-lived. The long-term impact of ECT on the course of schizophrenia in patients incompletely responsive to clozapine is not fully elucidated.
Starting Page	547
Ending Page	556
Page Count	10
File Format	PDF HTM / HTML
DOI	10.1016/S0278-5846(99)00015-9
Alternate Webpage(s)	https://api.elsevier.com/content/article/pii/S0278584699000159
Alternate Webpage(s)	https://www.sciencedirect.com/science/article/pii/S0278584699000159?dgcid=api_sd_search-api-endpoint
PubMed reference number	10378236
Alternate Webpage(s)	https://doi.org/10.1016/S0278-5846%2899%2900015-9
Journal	Medline
Volume Number	23
Journal	Progress in Neuro-Psychopharmacology and Biological Psychiatry
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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