NDLI: Endogenous regulation of serotonin release in the hamster suprachiasmatic nucleus.

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Endogenous regulation of serotonin release in the hamster suprachiasmatic nucleus.

Content Provider	Semantic Scholar
Author	Dudley, Tracey Dinardo, L. A. Glass, John David
Copyright Year	1998
Abstract	Serotonin (5-HT) has been strongly implicated in the regulation of the mammalian circadian clock located in the suprachiasmatic nuclei (SCN). However, little is known of the pattern of neuronal 5-HT release in the SCN or of the factors involved in regulating its release. Using in vivo microdialysis, we demonstrated the existence of a daily rhythm in the output of 5-HT in the SCN of freely behaving hamsters. This rhythm was characterized by a sharp increase in release from a nadir during late midday to peak levels at the light/dark transition. Output declined to basal levels throughout the remainder of the night. A similar pattern also was evident under constant darkness, with increased 5-HT output occurring at the onset of subjective night. Locomotor activity induced by exposure to a novel running wheel had a pronounced phase-dependent effect on 5-HT release in the SCN, with stimulation during the light phase and suppression during the late dark phase. Systemic application of the somatodendritic 5-HT1A agonist BMY 7378 had a significantly greater suppressive effect on 5-HT release in the SCN during the late dark phase compared with mid light phase, indicating that a variation in raphe autoreceptor response may underlie the time-dependent effects of wheel running on 5-HT release. Collectively, these results show that the daily rhythm in output of 5-HT in the SCN is generated endogenously, and that behavioral state can strongly influence serotonergic activity in the circadian clock in a phase-dependent manner.
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://www.jneurosci.org/content/jneuro/18/13/5045.full.pdf
PubMed reference number	9634570v1
Volume Number	18
Issue Number	13
Journal	The Journal of neuroscience : the official journal of the Society for Neuroscience
Language	English
Access Restriction	Open
Subject Keyword	Autoreceptors BMY 7378 Cell Nucleus Cerebellar Nuclei Circadian Clocks Hamsters Mammals Microdialysis Structure of suprachiasmatic nucleus regulation of serotonin secretion
Content Type	Text
Resource Type	Article

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