NDLI: Diagnostic significance of plasma osteopontin in hepatitis C virus-related hepatocellular carcinoma.

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Diagnostic significance of plasma osteopontin in hepatitis C virus-related hepatocellular carcinoma.

Content Provider	Semantic Scholar
Author	Abdel-Aleem, Ashraf Ali, Ahmed Shaker Saber, Rafet A. Shatat, Mohammed Rahem, Doaa Abdel Sayed, Douaa M.
Copyright Year	2011
Abstract	BACKGROUND AND AIM Outcome of hepatocellular carcinoma (HCC) depends mainly on its early diagnosis. The performance of traditional biomarkers is not satisfactory. Osteopontin (OPN) is of potential importance. This study aim to assess the diagnostic value of plasma OPN compared with alpha-fetoprotein (AFP) for the diagnosis of HCV- related HCC. METHODS We recruited 113 HCC patients compared with 120 matched cirrhotic patients and 120 Controls. The plasma level of OPN and serum AFP for all participants were assessed. RESULTS The median plasma OPN level was significantly higher in the HCC group than in the cirrhotic patient group or in the normal control group (p-value < 0.001), while OPN levels were not differed significantly in correlation with the degree of liver function deterioration in terms of advanced Child-Pugh class (p-value < 0.9). The diagnostic efficacy of OPN were superior to AFP in terms of AUC, sensitivity, specificity, PPV and NPV either in diagnosis of early or late stages of HCC (0.88 vs. 0.56; P = 0.0001, 0.991vs. 0.899; p = 0.01; respectively). CONCLUSION Plasma OPN level is a potential diagnostic marker for HCC, especially among high-risk group of patients. These values extend beyond the traditional tumor biomarkers as AFP, as it possesses good prognostic value.
Starting Page	296
Ending Page	305
Page Count	10
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://annalsofhepatology.com.mx/revista/numeros/2011/HP113-07-Diagnostic.pdf
PubMed reference number	21677331v1
Volume Number	10
Issue Number	3
Journal	Annals of hepatology
Language	English
Access Restriction	Open
Subject Keyword	Adrenergic alpha-Agonists Biological Markers Biomarkers, Tumor Chemical and Drug Induced Liver Injury Child-Pugh Clinical Classification Diagnostic Factor Early Diagnosis Fetal Proteins Hepatitis C virus Liver carcinoma Neoplasms Nucleopolyhedrovirus P-Value Patients alpha-Mannosidosis osteopontin
Content Type	Text
Resource Type	Article

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