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Statins reduce neurologic injury in asymptomatic carotid endarterectomy patients.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Heyer, Eric J. Mergeche, Joanna L. Bruce, Samuel S. Ward, Justin T. Stern, Yaakov Anastasian, Zirka H. Quest, Donald O. Solomon, Robert A. Todd, George J. Benvenisty, Alan I. Mckinsey, James F. Nowygrod, Roman Morrissey, Nicholas J. Connolly, E. Sander |
| Copyright Year | 2013 |
| Abstract | BACKGROUND AND PURPOSE Statins are neuroprotective in a variety of experimental models of cerebral injury. We sought to determine whether patients taking statins before asymptomatic carotid endarterectomy exhibit a lower incidence of neurological injury (clinical stroke and cognitive dysfunction). METHODS A total of 328 patients with asymptomatic carotid stenosis scheduled for elective carotid endarterectomy consented to participate in this observational study of perioperative neurological injury. RESULTS Patients taking statins had a lower incidence of clinical stroke (0.0% vs 3.1%; P=0.02) and cognitive dysfunction (11.0% vs 20.2%; P=0.03). In a multivariate regression model, statin use was significantly associated with decreased odds of cognitive dysfunction (odds ratio, 0.51 [95% CI, 0.27-0.96]; P=0.04). CONCLUSIONS Preoperative statin use was associated with less neurological injury after asymptomatic carotid endarterectomy. These observations suggest that it may be possible to further reduce the perioperative morbidity of carotid endarterectomy. Clinical Trial Registration- URL: http://www.clinicaltrials.gov. Unique identifier: NCT00597883. |
| Starting Page | 1819 |
| Ending Page | 1821 |
| Page Count | 3 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://columbianeurology.org/sites/default/files/statinsreduce.pdf |
| Alternate Webpage(s) | http://stroke.ahajournals.org/content/strokeaha/44/4/1150.full.pdf |
| Alternate Webpage(s) | http://stroke.ahajournals.org/content/strokeaha/early/2013/02/12/STROKEAHA.111.000362.full.pdf?download=true |
| Alternate Webpage(s) | http://stroke.ahajournals.org/content/strokeaha/44/4/1150.full.pdf?download=true |
| Alternate Webpage(s) | http://stroke.ahajournals.org/content/strokeaha/early/2013/02/12/STROKEAHA.111.000362.full.pdf |
| PubMed reference number | 23404722v1 |
| Alternate Webpage(s) | https://doi.org/10.1161/STROKEAHA.111.000362 |
| DOI | 10.1161/strokeaha.111.000362 |
| Journal | Stroke |
| Volume Number | 44 |
| Issue Number | 4 |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Brain Injuries Carotid Endarterectomy Carotid Stenosis Cerebrovascular accident Cognition Disorders Impaired cognition Morbidity - disease rate Odds Ratio Patients Schedule (document type) Simvastatin Trauma, Nervous System Uniform Resource Locator nervous system disorder |
| Content Type | Text |
| Resource Type | Article |
