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Cl− channels are randomly activated by continuous GABA secretion in cultured embryonic rat hippocampal neurons
| Content Provider | Semantic Scholar |
|---|---|
| Author | Valeyev, Alexander Cruciani, Ricardo Alberto Lange, G. David Smallwood, Victoria Barker, Jeffery L. |
| Copyright Year | 1993 |
| Abstract | Throughout the adult vertebrate central nervous system (CNS) gamma-aminobutyric acid (GABA) mediates transient Cl- conductances commonly identified as fast, Cl(-)-dependent inhibitory synaptic signals [Prog. Neurobiol., 36 (1991) 35-92]. In the rat hippocampus Cl(-)-dependent excitatory transients mediated by GABA emerge during the first postnatal week superimposed on a steady-state baseline that is also Cl(-)- and GABA-dependent [Int. J. Dev. Neurosci., 8 (1990) 481-490]. Here we report that many embryonic rat hippocampal neurons cultured for hours to days exhibit random fluctuations in Cl- channel activity that are mediated by continuous secretion of GABA in the absence of transients. Thus, GABA is broadcast tonically before it is released transiently. |
| Starting Page | 199 |
| Ending Page | 203 |
| Page Count | 5 |
| File Format | PDF HTM / HTML |
| PubMed reference number | 8397353 |
| Journal | Medline |
| Volume Number | 155 |
| Alternate Webpage(s) | https://api.elsevier.com/content/article/pii/030439409390707R |
| Alternate Webpage(s) | https://www.sciencedirect.com/science/article/pii/030439409390707R?dgcid=api_sd_search-api-endpoint |
| Alternate Webpage(s) | https://doi.org/10.1016/0304-3940%2893%2990707-R |
| Journal | Neuroscience Letters |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
