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Assessment of Overall Survival Benefits in Patients Undergoing Complete Hepatectomy for Synchronous Colorectal Cancer With Liver and Lung Metastases
| Content Provider | Semantic Scholar |
|---|---|
| Author | Arvide, Elsa Melissa Velasco, Jenilette Dames |
| Copyright Year | 2016 |
| Abstract | © 2016 Harborside Press® Overall survival (OS) is a statistical term referring to the percentage of a population in a group who are alive after a defined length of time, usually years. For example, a 5-year OS rate is the percentage of people who are alive 5 years after diagnosis or 5 years after the start of therapy. In surgical studies, OS is a universally accepted measure of direct benefit and can be easily and precisely measured. In general, OS is a common endpoint that is used to measure the success and efficacy of surgical treatments. In recent decades, surgical treatment of stage IV colorectal cancer has evolved considerably, allowing patients to have longer OS (Zisis et al., 2013). Furthermore, in patients undergoing hepatic resection, improvements in systemic therapy for stage IV colorectal cancer have significantly doubled the OS rate (Kim et al., 2012). Hepatectomy is now performed in 25% of patients with colorectal liver metastases (CLM), resulting in a 5-year OS rate up to 58% (Abdalla et al., 2004; Choti et al., 2002; Kopetz et al., 2009; Pawlik et al., 2005). Unfortunately, the remaining 75% of patients with CLM will not undergo hepatectomy, for reasons such as the presence of extrahepatic metastases, most commonly lung metastases (Hecht et al., 2009). The study by Mise et al. (2015a) discussed in depth in the article by Horner and Lencioni on page 781 if this issue addressed the benefits of resection of CLM in patients with synchronous lung metastases, even when the lung metastases are not resected. The findings of this study suggest the possibility of expanding Section Editors: Jeannine M. Brant, Sandra E. Kurtin, Constance Visovsky, and Rita Wickham |
| Starting Page | 788 |
| Ending Page | 792 |
| Page Count | 5 |
| File Format | PDF HTM / HTML |
| PubMed reference number | 29670814v1 |
| Volume Number | 7 |
| Journal | Journal of the advanced practitioner in oncology |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Biliary Atresia Colorectal Carcinoma Excision Hepatectomy Liver neoplasms Neoplasm Metastasis Non-Small Cell Lung Carcinoma Operative Surgical Procedures Overall Survival Patients Stage IV Colorectal Cancer benefit liver metastases lung metastases |
| Content Type | Text |
| Resource Type | Article |
