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Low-density lipoprotein, non-high-density lipoprotein, and apolipoprotein B as targets of lipid-lowering therapy.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Grundy, Scott M. |
| Copyright Year | 2002 |
| Abstract | Although low-density lipoprotein (LDL) is widely recognized as the major atherogenic lipoprotein and the primary target of lipid-lowering therapy,1 other lipoprotein species nonetheless appear to be involved in atherogenesis. These include very low-density lipoproteins (VLDL), intermediate-density lipoproteins (IDL), and highdensity lipoproteins (HDL). Both VLDL and IDL are triglyceride-rich lipoproteins (TGRLP). Thus, in the aftermath of unequivocal evidence that LDL lowering reduces risk for major coronary events and stroke,2 the field of lipid study is turning more of its attention to the other lipoproteins that appear to be involved in atherosclerosis. The recent Adult Treatment Panel III (ATP III) report1 of the National Cholesterol Education Program has summarized our current understanding of the relationship between other lipoprotein species and risk for coronary heart disease (CHD). |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://circ.ahajournals.org/content/circulationaha/106/20/2526.full.pdf?download=true |
| PubMed reference number | 12427645v1 |
| Volume Number | 106 |
| Issue Number | 20 |
| Journal | Circulation |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Apolipoproteins B Atherosclerosis Choline Dehydrogenase, Mitochondrial Coronary heart disease Heart Diseases High Density Lipoproteins Intermediate density lipoprotein cholesterol measurement (procedure) Lipoproteins, IDL Low sodium diet Low-Density Lipoproteins Triglycerides |
| Content Type | Text |
| Resource Type | Article |
