Loading...
Please wait, while we are loading the content...
Similar Documents
Mechanisms underlying the antireflux action of fundoplication.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Ireland, Alan Holloway, Richard H. Toouli, James Dent, John |
| Copyright Year | 1993 |
| Abstract | The effect of fundoplication on patterns of gastro-oesophageal reflux and the underlying motor mechanisms were investigated in 18 patients with symptomatic reflux. Oesophageal motility and pH were recorded concurrently after a standard meal. Studies were performed preoperatively and from 5 to 27 months after surgery. Fundoplication virtually eliminated reflux in all but three patients. Control of reflux was associated with a 50% fall in the number of transient lower oesophageal sphincter relaxations, a fall in the proportion of transient lower oesophageal sphincter relaxations accompanied by reflux from 47% to 17%, and an increase in the mean residual pressure at the gastro-oesophageal junction during swallow induced lower oesophageal sphincter relaxation from 0.7 mm Hg to 6.0 mm Hg. Basal pressure at the gastro-oesophageal junction rose from 10.9 mm Hg to 14.5 mm Hg, however, there was no correlation between postoperative reflux and basal gastro-oesophageal junction pressure. These findings suggest that the anti-reflux effects of fundoplication result from changes in the mechanical behaviour of the gastro-oesophageal junction that result in incomplete abolition of the high pressure zone during lower oesophageal sphincter relaxation, and reduced triggering of transient lower oesophageal sphincter relaxations. |
| Starting Page | 1 |
| Ending Page | 4 |
| Page Count | 4 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://gut.bmj.com/content/gutjnl/34/3/303.full.pdf |
| PubMed reference number | 8472975v1 |
| Volume Number | 34 |
| Issue Number | 3 |
| Journal | Gut |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | CDISC SDTM Gastrointestinal Test Name Terminology Esophagogastric fundoplasty Gastroesophageal reflux disease Mercury Patients Sphincter Stomach |
| Content Type | Text |
| Resource Type | Article |
