NDLI: Expression Levels of Estrogen Receptor-α, Estrogen Receptor-β, Coactivators, and Corepressors in Breast Cancer

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Expression Levels of Estrogen Receptor-α, Estrogen Receptor-β, Coactivators, and Corepressors in Breast Cancer

Content Provider	Semantic Scholar
Author	Kurebayashi, Junichi Otsuki, Takemi Kunisue, Hironori Tanaka, Katsuhiko Yamamoto, Shigeru Sonoo, Hiroshi
Copyright Year	2000
Abstract	Recent studies have indicated that a complex machinery of transactivation of target genes by estrogen or antiestrogen through estrogen receptor (ER) exists. However, the substantial roles of ER-β, coactivators, and corepressors in the development and progression of breast cancer remain to be elucidated. To obtain some clue to these roles, we screened the expression levels of ER-α, ER-β, coactivators (SRC-1, TIF2, AIB1, CBP, and P/CAF) and corepressors (N-CoR and SMRT) in 6 normal mammary glands, 6 intraductal carcinomas, 22 invasive ductal carcinomas, and 7 breast cancer cell lines using a multiplex reverse transcription-PCR. ER-α mRNA expression levels significantly correlated with ER-α protein levels measured by enzyme immunoassay in the breast cancer tissues and cell lines. A significant correlation of expression levels was observed between ER-α and TIF2, AIB1, P/CAF, and N-CoR, and between ER-β and AIB1 and CBP in the tissue samples. A significant correlation was also observed between ER-α and ER-β and between ER-β and CBP in the cell lines. The expression levels of ER-α, TIF2, and CBP were significantly higher in the intraductal carcinomas than those in the normal mammary glands. In addition, the expression levels of ER-α and N-CoR were significantly higher in the intraductal carcinomas than those in the invasive ductal carcinomas. These findings suggest a positive correlation of expression levels among ER-α and cofactors and among ER-β and cofactors, an up-regulation of expression levels of ER-α and cofactors during the development of intraductal carcinomas from normal mammary glands, and a decrease in their expression levels during the progression of breast cancer.
Starting Page	512
Ending Page	518
Page Count	7
File Format	PDF HTM / HTML
Volume Number	6
Alternate Webpage(s)	http://clincancerres.aacrjournals.org/content/clincanres/6/2/512.full.pdf
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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