NDLI: Gonococcal pilin variants in experimental gonorrhea

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Gonococcal pilin variants in experimental gonorrhea

Content Provider	Semantic Scholar
Author	Swanson, John Robbins, Ken Barrera, Osmar Corwin, David Boslego, J. Ciak, Jennie Blake, Milan Koomey, J. Michael
Copyright Year	1987
Abstract	When pilus+ Gc were introduced into a male subject's urethra, they gave rise to pilus+ variants whose pilin mRNAs differed from that of input Gc. The differences stemmed from the Gc genome's single complete pilin gene having undergone gene conversion by different partial pilin genes' sequences and by different length stretches of a single partial pilin gene. In some instances, the variant's pilin mRNA appeared to reflect two independent gene-conversion events that used sequences from two different partial pilin genes. The resulting variants' pilins exhibited antigenic differences compared with the pilin polypeptide of input Gc; these differences were discernible by immunoblotting with mAbs. Amino acid and antigenic changes occurred in a segment of the variants' pilin polypeptides that previously was thought to be conserved or constant in sequence.
Starting Page	1344
Ending Page	1357
Page Count	14
File Format	PDF HTM / HTML
DOI	10.1084/jem.165.5.1344
PubMed reference number	3106555
Journal	Medline
Volume Number	165
Alternate Webpage(s)	http://jem.rupress.org/content/jem/165/5/1344.full.pdf
Alternate Webpage(s)	https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/fb/9c/je16551344.PMC2188307.pdf
Alternate Webpage(s)	https://doi.org/10.1084/jem.165.5.1344
Journal	The Journal of experimental medicine
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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