NDLI: Ranitidine pharmacokinetics in newborn infants.

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Ranitidine pharmacokinetics in newborn infants.

Content Provider	Semantic Scholar
Author	Fontana, Marcelo Massironi, E. Rossi, Anthony Vaglia, P. Gancia, G. P. Tagliabue, Paola Principi, Nicola
Copyright Year	1993
Abstract	Few data are available for ranitidine pharmacokinetics in the first few days of life. Twenty seven newborn infants were treated with intravenous ranitidine because they were vomiting blood, although they had a negative Apt's test. Each infant provided two blood samples at randomly selected times 30-360 minutes after a 2.4 mg/kg intravenous bolus of ranitidine. A single exponential equation for the concentration-time graph was fitted to the mean serum concentrations at different times. From this model the following mean (SD) measurements wer derived: elimination half life, 207.1 (19.1) minutes; total volume of distribution, 1.52 (0.91) l/kg; and total plasma clearance, 5.02 (0.46) ml/kg/min. Assuming that these measurements do not change with different administered doses, regimens can be derived to assist in planning ranitidine treatment in newborn infants.
Starting Page	131
Ending Page	136
Page Count	6
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://adc.bmj.com/content/archdischild/68/5_Spec_No/602.full.pdf
PubMed reference number	8323366v1
Volume Number	68
Issue Number	5
Journal	Archives of disease in childhood
Language	English
Access Restriction	Open
Subject Keyword	Blood specimen Elimination Half Life Excretory function Hematological Disease Infant, Newborn LYPLA2P1 gene Milliliter per Kilogram per Minute Milliliter per gram Physiological Sexual Disorders Ranitidine Seizures drug distribution volume exponential
Content Type	Text
Resource Type	Article

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