NDLI: Interleukin 4 (B-cell stimulatory factor 1) can enhance or antagonize the factor-dependent growth of hemopoietic progenitor cells.

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Interleukin 4 (B-cell stimulatory factor 1) can enhance or antagonize the factor-dependent growth of hemopoietic progenitor cells.

Content Provider	Semantic Scholar
Author	Rennick, Donna M. Yang, Guang Muller-Sieburg, Christa E. Smith, Corey Arai, Naoko Takabe, Y. Gemmell, Lorraine
Copyright Year	1987
Abstract	Our studies show that although interleukin 4 (IL-4) fails to stimulate significant colony formation by bone marrow progenitor cells, it enhances erythroid, granulocyte, macrophage, and mast-cell colony formation when used as a costimulant with erythropoietin, granulocyte colony-stimulating factor, macrophage colony-stimulating factor, and interleukin 3 (IL-3), respectively. In contrast, IL-4 suppresses IL-3-dependent colony formation by granulocyte and macrophage progenitor cells and by multipotential progenitor cells. Furthermore, it appears to inhibit the in vitro generation of colony-forming progenitor cells from immature IL-3-dependent stem cells. We also found that IL-4 inhibits stromal cell-dependent growth of bone marrow-derived pre-B cells. The ability of IL-4 to directly or indirectly regulate both positive and negative aspects of progenitor cell growth is discussed.
Starting Page	1
Ending Page	380
Page Count	380
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://www.pnas.org/content/84/19/6889.full.pdf
PubMed reference number	3498944v1
Volume Number	84
Issue Number	19
Journal	Proceedings of the National Academy of Sciences of the United States of America
Language	English
Access Restriction	Open
Subject Keyword	Bone Marrow Colony-Stimulating Factors Granulocyte-Macrophage Colony-Stimulating Factor Interleukin-3 Interleukin-4 Interleukins Leukemia, B-Cell Macrophage Colony-Stimulating Factor Stem cells Stimulation (motivation) Stromal Cells cell growth granulocyte
Content Type	Text
Resource Type	Article

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