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Antimicrobial activities of amine- and guanidine-functionalized cholic acid derivatives.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Li, Chenghong Lewis, Margaret R. Gilbert, A. B. Noel, Martine Scoville, David H. Allman, Glenn W. Savage, Paul B. |
| Copyright Year | 1999 |
| Abstract | Compounds in a series of cholic acid derivatives, designed to mimic the activities of polymyxin B and its derivatives, act as both potent antibiotics and effective permeabilizers of the outer membranes of gram-negative bacteria. Some of these compounds rival polymyxin B in antibacterial activity against gram-negative bacteria and are also very active against gram-positive organisms. Other compounds interact synergistically with hydrophobic antibiotics to inhibit bacterial growth. |
| File Format | PDF HTM / HTML |
| DOI | 10.1128/aac.43.6.1347 |
| Alternate Webpage(s) | http://citeseerx.ist.psu.edu/viewdoc/download?doi=10.1.1.516.6834&rep=rep1&type=pdf |
| Alternate Webpage(s) | http://aac.asm.org/content/43/6/1347.full.pdf |
| PubMed reference number | 10348750 |
| Alternate Webpage(s) | https://doi.org/10.1128/aac.43.6.1347 |
| Journal | Medline |
| Volume Number | 43 |
| Issue Number | 6 |
| Journal | Antimicrobial agents and chemotherapy |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
