Single-neuron activity and tissue oxygenation in the cerebral cortex.

Content Provider	Semantic Scholar
Author	Thompson, Jeffrey K. Peterson, Matthew R. Freeman, Ralph D.
Copyright Year	2003
Abstract	Blood oxygen level-dependent functional magnetic resonance imaging uses alterations in brain hemodynamics to infer changes in neural activity. Are these hemodynamic changes regulated at a spatial scale capable of resolving functional columns within the cerebral cortex? To address this question, we made simultaneous measurements of tissue oxygenation and single-cell neural activity within the visual cortex. Results showed that increases in neuronal spike rate were accompanied by immediate decreases in tissue oxygenation. We used this decrease in tissue oxygenation to predict the orientation selectivity and ocular dominance of neighboring neurons. Our results establish a coupling between neural activity and oxidative metabolism and suggest that high-resolution functional magnetic resonance imaging may be used to localize neural activity at a columnar level.
Starting Page	585
Ending Page	600
Page Count	16
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://www.tsolab.org/jclub/20031006/freeman.pdf
PubMed reference number	12586942v1
Volume Number	299
Issue Number	5609
Journal	Science
Language	English
Access Restriction	Open
Subject Keyword	Cell Respiration Cerebral cortex Dominance, Ocular Hemodynamics Inference Magnetic Resonance Imaging Neurons Oxygen
Content Type	Text
Resource Type	Article