NDLI: Platinum-based chemotherapy for recurrent CNS tumours in young patients.

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Platinum-based chemotherapy for recurrent CNS tumours in young patients.

Content Provider	Semantic Scholar
Author	Douek, Ellis Kingston, Judith E. Malpas, James S. Plowman, Piers Nicholas
Copyright Year	1991
Abstract	Twenty nine patients (median age 12 years) with a CNS tumour, received platinum-based chemotherapy for assessable disease. In 23 patients there was an objective response with improvement lasting for a median duration of 11 months. There was little difference in the response to cisplatinum or carboplatin therapy. The response rates in specific disease groups were: medulloblastoma 8/10, two with a complete response (CR) and six with a partial response (PR); ependymoma 1/5 PR; pineal retinoblastoma 5/5 with three CR and two PR; primitive neurectodermal tumours (PNET) 2/2 PR and pineal germ cell tumours 6/6 with four CR and two PR. It is concluded that platinum-based chemotherapy has a beneficial effect on CNS tumours of the CNS, especially medulloblastoma, ectopic intracranial retino-blastoma and pineal germ cell tumours.
Starting Page	2105
Ending Page	2110
Page Count	6
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://jnnp.bmj.com/content/jnnp/54/8/722.full.pdf
PubMed reference number	1940946v1
Volume Number	54
Issue Number	8
Journal	Journal of neurology, neurosurgery, and psychiatry
Language	English
Access Restriction	Open
Subject Keyword	Carboplatin Central Nervous System Neoplasms Cisplatin Ectopic Graft Ependymoma Ewings sarcoma-primitive neuroectodermal tumor (PNET) Germ Cells Liver neoplasms Medulloblastoma Paget's Disease, Mammary Patients Pineal Region Germ Cell Tumor Pineal gland Platinum Pleuropulmonary blastoma central nervous system tumor, pediatric recurrent childhood brain stem glioma recurrent childhood supratentorial primitive neuroectodermal tumors
Content Type	Text
Resource Type	Article

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