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Relation entre le cytosquelette de filaments intermédiaires et la signalisation oncogénique des isoformes d'AKT au cours de la progression tumorale
| Content Provider | Semantic Scholar |
|---|---|
| Author | Fortier, A. |
| Copyright Year | 2013 |
| Abstract | Keratin 8 and 18 are simple epithelial intermediate filament (IF) proteins, whose expression is differentiationand tissue-specifie, and is maintained during tumorigenesis. Vimentin IF is often co-expressed with keratins in cancer cells. Recently, IF have been proposed to be involved in signaling pathways regulating cell growth, death and motility. The PI3K1Akt pathway plays a pivotaI role in these processes. Thus, we investigated the role of Akt (1 and 2) in regulating IF expression in different epithelial cancer celllines. Over-expression of Akt1 increases K8118 proteins. Akt2 upregulates K18 and vimentin expression by an increased rnRNA stability. To our knowledge, these results represent the frrst indication that Akt isoforms regulate IF expression and support the hypothesis that IFs are involved in PI3K1Akt pathway. |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://depot-e.uqtr.ca/6964/1/030590451.pdf |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
