NDLI: Contribution of monoamine oxidases to vascular oxidative stress in patients with end-stage renal disease requiring hemodialysis.

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Contribution of monoamine oxidases to vascular oxidative stress in patients with end-stage renal disease requiring hemodialysis.

Content Provider	Semantic Scholar
Author	Uțu, Diana Pantea, Stelian Dorian Duicu, Oana M. Muntean, Danina Mirela Sturza, Adrian
Copyright Year	2017
Abstract	Arteriovenous fistula (AVF) is the "lifeline" for patients with end-stage renal disease (ESRD) undergoing hemodialysis. AVF maturation failure is a poorly understood process, one of the contributors being endothelial dysfunction due to oxidative stress. Monoamine oxidases (MAOs) A and B were recently identified as novel sources of vascular oxidative stress. The aim of the present study was to assess the contribution of MAOs to the endothelial dysfunction in patients with ESDR with indication of hemodialysis. Fragments of brachial artery collaterals were harvested from ESRD patients during the surgical procedure aimed at creating the vascular access in the cubital fossa. The effect of increasing concentrations (10, 30, 100 μmol/L) of the irreversible MAO-A inhibitor, clorgyline, and MAO-B inhibitor, selegiline, on endothelial-dependent relaxation (EDR) in response to cumulative doses of acetylcholine was studied in isolated phenylephrine-preconstricted vascular rings. Hydrogen peroxide (H2O2) production was assessed using ferrous oxidation xylenol orange assay. We showed that incubation of brachial rings with MAO inhibitors significantly improved EDR and attenuated H2O2 generation in patients with ESRD. MAO-related oxidative stress might contribute to the primary dysfunction/non-maturation of the AVF and MAO inhibitors could improve maturation and long-term patency of the vascular access in dialysis patients.
Starting Page	1383
Ending Page	1388
Page Count	6
File Format	PDF HTM / HTML
DOI	10.1139/cjpp-2017-0067
PubMed reference number	28753408
Journal	Medline
Volume Number	95
Issue Number	11
Alternate Webpage(s)	https://tspace.library.utoronto.ca/bitstream/1807/78818/1/cjpp-2017-0067.pdf
Alternate Webpage(s)	https://doi.org/10.1139/cjpp-2017-0067
Journal	Canadian journal of physiology and pharmacology
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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