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Nocturnal Hypoxemia, But Not Sleep Apnea, Is Associated With a Poor Prognosis in Patients With Pulmonary Arterial Hypertension.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Nagaoka, Mika Goda, Ayumi Takeuchi, Kaori Kikuchi, Hanako Finger, Mayumi Y. Inami, Takumi Soejima, Kyoko Satoh, T. |
| Copyright Year | 2018 |
| Abstract | BACKGROUND Sleep apnea (SA) can cause repeated nocturnal arterial oxygen desaturation and result in acute increase in pulmonary arterial pressure (PAP). The presence of SA is associated with a poor prognosis in patients with chronic left-sided heart failure, but little is known for patients with pulmonary arterial hypertension (PAH). Methods and Results: We enrolled 151 patients with PAH (44±16 years old, male/female=37/114). They were all in the Nice Classification group 1 (idiopathic PAH/associated PAH=52/48%, mean PAP of 46±16 mmHg). They underwent right-heart catheterization and a sleep study with simplified polysomnography. Averaged percutaneous oxygen saturation (SpO2) during sleep was measured and an apnea-hypopnea index >5 was defined as SA. SA was noted in 58 patients (obstructive SA/central SA: 29/29). Over an average follow-up of 1,170±763 days, 32 patients died. By Kaplan-Meier analysis, there was no significant difference in deaths of patients with and without SA (χ2=2.82, P=0.093). On the other hand, the mortality in patients with lower averaged SpO2 was significantly higher than in those with higher averaged SpO2 (χ2=14.7, P<0.001) and that was the only independent variable related to death in multivariate Cox proportional hazards analysis. CONCLUSIONS SA in patients with PAH was not associated with worse prognosis, unlike left ventricular heart failure, but nocturnal hypoxemia was related to poor prognosis. |
| Starting Page | 3076 |
| Ending Page | 3081 |
| Page Count | 6 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | https://www.jstage.jst.go.jp/article/circj/advpub/0/advpub_CJ-18-0636/_pdf/-char/en |
| PubMed reference number | 30333436v1 |
| Alternate Webpage(s) | https://doi.org/10.1253/circj.CJ-18-0636 |
| DOI | 10.1253/circj.cj-18-0636 |
| Journal | Circulation journal : official journal of the Japanese Circulation Society |
| Volume Number | 82 |
| Issue Number | 12 |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Cardiac Catheterization Procedures Cessation of life Forecast of outcome Hypertensive disease Hypoxia Idiopathic Pulmonary Fibrosis Kidney Failure, Chronic Left-Sided Heart Failure Oxygen saturation test result Patients Polysomnography Pulmonary Hypertension Sleep Apnea Syndromes Sleep Apnea, Obstructive proteasome storage granule pulmonary arterial pressure |
| Content Type | Text |
| Resource Type | Article |
