NDLI: Chromosomal location of a mutation causing chloramphenicol resistance in Escherichia coli K 12.

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Chromosomal location of a mutation causing chloramphenicol resistance in Escherichia coli K 12.

Content Provider	Semantic Scholar
Author	Reeve, E. C. R. Suttie, David J. R.
Copyright Year	1968
Abstract	Mutants of Escherichia coli K12, resistant to a low level of chloramphenicol, are easily selected by plating about 10 bacteria on antibiotic agar. Such mutants probably occur at more than one genetic locus, since they show several different patterns of resistance to CmJ, Tc and Pm (Reeve & Bishop, 1965; Reeve, 1966). In certain instances genetically determined resistance to a variety of antibiotics in the Enterobacteriaceae depends on extra-chromosomal genes, attached to or at least transferred by RTF agents (Watanabe, 1963; Anderson & Lewis, 1965a, b); and the question arises whether low-level resistance to Cm is due to chromosomal or extra-chromosomal genes. In this paper we show that the mutation previously referred to as la (Reeve, 1966), giving a relatively high level of resistance to Cm in comparison to other one-step mutants, has a chromosomal location and is closely linked to the chromosomal attachment site of phage A. Transduction tests with P i indicate that there is little phenotypic lag in the expression of this mutant gene after transfer to a new strain.
Starting Page	97
Ending Page	104
Page Count	8
File Format	PDF HTM / HTML
DOI	10.1017/S0016672300011228
PubMed reference number	4869961
Journal	Medline
Volume Number	11
Issue Number	1
Alternate Webpage(s)	https://www.cambridge.org/core/services/aop-cambridge-core/content/view/S0016672300011228
Alternate Webpage(s)	https://doi.org/10.1017/S0016672300011228
Journal	Genetical research
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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