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Dynamic Polyconjugates ( DPC ) Technology : An Elegant Solution to the siRNA Delivery Problem
| Content Provider | Semantic Scholar |
|---|---|
| Author | Lewis, David E. |
| Copyright Year | 2011 |
| Abstract | Harnessing biological pathways to treat disease is a highly attractive and potentially powerful approach. Biological pathways are extraordinarily efficient in carrying out their function in the body; such efficiencies are rarely achieved using conventional medicines. One pathway that is currently being explored for therapeutic applications is RNA interference (RNAi). RNAi was discovered by Fire and Mello, for which they were awarded the Nobel Prize in Physiology or Medicine in 2006. The RNAi pathway is present in all cells of the human body and operates as a sequence-specific gene silencing mechanism triggered by the presence of double-stranded RNA (dsRNA). In 2001, Tuschl discovered that short versions of dsRNA, known as small interfering RNAs (siRNAs), could be used to trigger RNAi. siRNA, and its analogsare presently being evaluated as drugs to target genes associated with disease. With the sequence of the human genome in hand and our increased understanding of the molecular basis of disease, RNAi is poised to be a transformative technology in the pharmaceutical industry. |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://www.biotechduediligence.com/uploads/6/3/6/7/6367956/arrowhead-research-corporation_-_dpc-technology-white-paper-november2011.pdf |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
